Directed by Judd Apatow
Written by Judd Apatow and Steve Carell
Starring Steve Carell, Catherine Keener, Paul Rudd, Romany Malco, Seth Rogen
The most recently released member of the Pantheon, this movie kind of defines raunchy comedy. The other side of it is that it's actually a very sweet movie and completely depends on Steve Carell's eminently likeable Andy. Everyone does what they're good at here, but Carell really owns it, with everything from uncomfortable and idiosyncratic teeth-picking to goofy voices, all of which ride on good characterization.
The unrated version and extras are actually worthwhile on the DVD.
The Forty-Year-Old Virgin at IMDB.